IKBIP

IKBIP (Inhibitor of Kappa Light Polypeptide Gene Enhancer in B-Cells, Inhibitor Protein): IKBIP is a protein involved in the negative regulation of the NF-κB signalling pathway. This pathway is essential for immune response, inflammation, and cell survival. IKBIP functions by inhibiting NF-κB activity in the cytoplasm, preventing its movement to the nucleus and the activation of specific target genes. Dysregulation of NF-κB signalling through IKBIP is linked to autoimmune diseases, chronic inflammation, and cancer, highlighting its key role in controlling immune and inflammatory processes.